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Review
. 2012 Jan;11(1):41-50.
doi: 10.1016/j.arr.2011.06.001. Epub 2011 Jun 13.

MicroRNAs as a novel cellular senescence regulator

Feng-Jiao Liu  1 , Tie Wen, Ling Liu
Affiliations
Review

MicroRNAs as a novel cellular senescence regulator

Feng-Jiao Liu et al. Ageing Res Rev. 2012 Jan.

Abstract

Cellular senescence is a program activated in normal cells in response to various types of stresses and is manifested by permanent arrest of cell cycle. Cellular senescence is closely related to tumor suppression, and may contribute to the ageing of organisms. The complex senescence cell phenotype has many different mechanisms. Recent studies have provided important insights regarding the role played by miRNAs during cellular senescence as a novel molecular mechanism. In this article, we will review the latest advances in the identification and validation of senescence-regulatory miRNAs and the possible mechanisms.

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