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. 2011 Jul 15;13(14):3746-9.
doi: 10.1021/ol2014347. Epub 2011 Jun 21.

Rh-catalyzed transannulation of N-tosyl-1,2,3-triazoles with terminal alkynes

Buddhadeb Chattopadhyay  1 , Vladimir Gevorgyan
Affiliations

Rh-catalyzed transannulation of N-tosyl-1,2,3-triazoles with terminal alkynes

Buddhadeb Chattopadhyay et al. Org Lett. .

Abstract

The first transannulation of 1,2,3-triazoles with terminal alkynes into pyrroles is reported. The reaction proceeds in the presence of a Rh(2)(oct)(4)/AgOCOCF(3) binary catalyst system providing a straightforward approach to 1,2,4-trisubstituted pyrroles in good to excellent yields.

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Figures

Scheme 1
Scheme 1
Proposed Mechanism for the Transannulation of N-tosyltriazoles with Terminal Alkynes
See this image and copyright information in PMC

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