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. 2011 Oct;38(5):437-40.
doi: 10.1111/j.1744-313X.2011.01023.x. Epub 2011 Jun 22.

Detection of two HLA-A alleles, A*31:30 and A*26:20, in two Taiwanese volunteer bone marrow donors by sequence-based typing

K L Yang  1 , S K Lee, C C Lin, S Jiang, H M Chiu, S Lin, Y C Chen, S P Chen, S Y Yang, Y F Jian, M H Shyr, C L Lin, P Y Lin
Affiliations

Detection of two HLA-A alleles, A*31:30 and A*26:20, in two Taiwanese volunteer bone marrow donors by sequence-based typing

K L Yang et al. Int J Immunogenet. 2011 Oct.

Abstract

We here report detection of a novel sequence of HLA-A*31:30 and a confirmatory sequence of HLA*26:20 from two Taiwanese individuals. The sequence of A*31:30 is identical to that of A*31:01:02 in exons 2 and 3, except one nucleotide (n.t.) substitution c.539T > G resulting in p.Leu180Trp. The sequence of A*26:20 is identical to A*26:01:01 in exons 2 and 3, except a segment of the sequence from n.t. 78 to n.t.102. The mismatched sequence segment is identical to a sequence segment of A*02:03:01, suggesting that the formation of A*26:20 was resulted from a DNA recombination event between A*26:01:01 and A*02:03:01 sequences. A*26:20 differs from A*26:01:01 with c.98A > T resulting in p.Tyr33Phe.

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