Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010:3:71-7.
doi: 10.2147/ceg.s10921. Epub 2010 Jun 29.

Time trends in incidence of peptic ulcer bleeding and associated risk factors in Norway 1985-2008

Kåre E Bakkevold  1
Affiliations

Time trends in incidence of peptic ulcer bleeding and associated risk factors in Norway 1985-2008

Kåre E Bakkevold. Clin Exp Gastroenterol. 2010.

Abstract

Objective: The aim of this study was to examine time trends in the incidence of peptic ulcer bleeding and risk factors in a defined geographical area in Norway.

Material and methods: Retrospective data were collected for 306 patients with bleeding peptic ulcers admitted to one hospital during the 1985-1986, 1995-1996, and 2007-2008 periods.

Results: The incidence in 1985-1986 was 52/100,000 and in 2007-2008 was 45/100,000. In the group aged 20-75 years, the incidence decreased by 54% from 54/100000 in 1985-1986 to 25/100000 in 2007-2008 (P = 0.001) and increased by 49% in the group aged >75 years from 272/100000 to 406/100000 (P = 0.0001). The use of aspirin or nonsteroidal anti-inflammatory steroid drugs (NSAIDs) was 31% in 1985-1986 and increased to 67% in 2007-2008 (P = 0.004). In patients using aspirin or NSAIDs, Helicobacter pylori was present in 73% in 1995-1996 and in 51% in 2007-2008. H. pylori infection declined from 84% to 52% between 1995-1996 and 2007-2008.

Conclusions: The incidence rate of peptic ulcer bleeding did not change between 1985-1986 and 2007-2008, but decreased in the age group ≤75 years and increased in the age group >75 years. The use of low-dose aspirin and NSAIDs increased substantially over time, and H. pylori infection was still present in 51% of these patients in 2007-2008.

Keywords: epidemiology; peptic ulcer bleeding; risk factors; time trends.

PubMed Disclaimer

References

    1. van Leerdam ME, Vreeburg EM, Rauws EA, et al. Acute upper GI bleeding: Did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol. 2003;98:1494–1499. - PubMed
    1. Ohmann C, Imhof M, Ruppert C, et al. Time trends in the epidemiology of peptic ulcer bleeding. Scand J Gastroenterol. 2005;40:914–920. - PubMed
    1. Theocharis GJ, Thomopoulos KC, Sakellaropoulos G, et al. Changing trends in the epidemiology and clinical outcome of acute upper gastrointestinal bleeding in a defined geographical area in Greece. J Clin Gastroenterol. 2008;42:128–133. - PubMed
    1. Loperfido S, Baldo V, Piovesana E, et al. Changing trends in acute upper GI bleeding: A population based study. Gastrointest Endosc. 2009;70(2):212–224. - PubMed
    1. Penston JG, Crombie IK, Waugh NR, et al. Trends in morbidity and mortality from peptic ulcer disease: Tayside versus Scotland. Aliment Pharmacol Ther. 1993;7:429–442. - PubMed