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. 2011:5:87-92.
doi: 10.4137/BCBCR.S7199. Epub 2011 May 18.

Hormone receptor status in breast cancer and its relation to age and other prognostic factors

Ali Pourzand  1 , M Bassir A Fakhree, Shahryar Hashemzadeh, Monireh Halimi, Amir Daryani
Affiliations

Hormone receptor status in breast cancer and its relation to age and other prognostic factors

Ali Pourzand et al. Breast Cancer (Auckl). 2011.

Abstract

Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers.

Patients and methods: We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement.

Results: There is a direct correlation between positive progesterone receptor status and being younger than 40 (P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages (P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression (P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant.

Conclusions: Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.

Keywords: age; breast cancer; estrogen receptor; lymph node metastasis; progesterone receptor.

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Figures

Figure 1.
Figure 1.
Younger women had tumors that were more likely to have higher stage (A), larger size (B), and progesterone receptor positive (C).
See this image and copyright information in PMC

References

    1. American Cancer Society Cancer Facts and Figures, 2004. 2004;3:10.
    1. Albain KS, Allred DC, Clark GM. Breast cancer outcome and predictor of outcome: are there age differentials? J Natl Cancer Inst Monogr. 1994;16:35–42. - PubMed
    1. Kollias J, Elston CW, Ellis IO, Robertson JF, Blamey RW. Early-onset breast cancer-histopathological and prognostic considerations. Br J Cancer. 1997;75:1318–23. - PMC - PubMed
    1. Shannon C, Smith IE. Breast cancer in adolescents and young women. Eur J Cancer. 2003;39:2632–42. - PubMed
    1. Anders CK, Hsu DS, Broadwater G, et al. Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression. J Clin Oncol. 2008;26:3324–30. - PubMed