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Case Reports
. 2012 Oct;16(5):395-7.
doi: 10.1007/s10151-011-0702-8. Epub 2011 Jun 22.

Local giant cell foreign body reaction after silicone injection for fecal incontinence in humans: two case reports

B van Wunnik  1 , A Driessen, C Baeten
Affiliations
Case Reports

Local giant cell foreign body reaction after silicone injection for fecal incontinence in humans: two case reports

B van Wunnik et al. Tech Coloproctol. 2012 Oct.

Abstract

Since the 1990s, one of the methods used for treating fecal incontinence due to internal anal sphincter defects has been the injection of bulking agents. The aim of this paper is to report two cases of local giant cell foreign body reaction after injection of PTQ(TM) in humans. To the best of the authors' knowledge, this is the first report of an adverse immune response to silicone injection in humans.

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Figures

Fig. 1
Fig. 1
This photograph shows a foreign body reaction with presence of numerous giant cells (H/E, 50x)
Fig. 2
Fig. 2
Large magnification reveals the presence of giant cells and foamy macrophages. The giant cells contain foreign material, which has an oily appearance (H/E, 200x)
See this image and copyright information in PMC

References

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