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Review
. 2011 Oct;39(4):187-90.
doi: 10.1097/JES.0b013e31822673f0.

Pigment epithelium-derived factor: a not so sympathetic regulator of insulin resistance?

Christopher Bell  1
Affiliations
Review

Pigment epithelium-derived factor: a not so sympathetic regulator of insulin resistance?

Christopher Bell. Exerc Sport Sci Rev. 2011 Oct.

Abstract

Pigment epithelium-derived factor (PEDF), an adipokine, is a regulator of oxidative stress, inflammation, angiogenesis, and insulin sensitivity. Contrary to animal and cell culture data, inhibition of the sympathoadrenal system does not affect serum PEDF in humans. However, during acute beta-adrenergic receptor stimulation serum PEDF concentration is decreased. PEDF may be involved in cross talk between adipose tissue and skeletal muscle.

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