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. 2011 Jun;84(2):103-8.

Close to home: a history of Yale and Lyme disease

Shana Elbaum-Garfinkle  1
Affiliations

Close to home: a history of Yale and Lyme disease

Shana Elbaum-Garfinkle. Yale J Biol Med. 2011 Jun.

Abstract

Yale scientists played a pivotal role in the discovery of Lyme disease and are credited as the first to recognize, name, characterize, and treat the affliction. Today, Lyme disease is the most commonly reported vector-borne illness in the United States, affecting approximately 20,000 people each year, with the incidence having doubled in the past 10 years [1]. Lyme disease is the result of a bacterial infection transmitted to humans through the bite of an infected deer tick, which typically results in a skin rash at the site of attack. While most cases, when caught early, are easily treated by antibiotic therapy, delayed treatment can lead to serious systemic side effects involving the joints, heart, and central nervous system. Here we review Yale's role in the discovery and initial characterization of Lyme disease and how those early discoveries are crucial to our current understanding of the disease.

Keywords: Lyme arthritis; Lyme disease.

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References

    1. Bacon RM, Kugeler KJ, Mead PS. Surveillance for Lyme Disease ― United States, 1992-2006. MMWR [Surveillance Summary] 2008;57(SS10):1–9. - PubMed
    1. Edlow JA. Bull’s Eye: Unraveling the Medical Mystery of Lyme Disease. New Haven: Yale University Press; 2003.
    1. Steere AC, Malawista SE, Snydman DR, Shope RE, Andiman WA, Ross MR. et al. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities. Arthritis Rheum. 1977;20(1):7–17. - PubMed
    1. Hellerstrom S. Erythema chronicum migrans Afzelius with meningitis. Acta Derm Venereol. 1951;31(2):227–234. - PubMed
    1. Steere AC, Hardin JA, Malawista SE. Erythema chronicum migrans and Lyme arthritis: cryoimmunoglobulins and clinical activity of skin and joints. Science. 1977;196(4294):1121–1122. - PubMed

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