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Review
. 2011 Jun 23:11:75.
doi: 10.1186/1471-2377-11-75.

Neuroregeneration in neurodegenerative disorders

Ana M Enciu  1 , Mihnea I Nicolescu, Catalin G Manole, Dafin F Mureşanu, Laurenţiu M Popescu, Bogdan O Popescu
Affiliations
Review

Neuroregeneration in neurodegenerative disorders

Ana M Enciu et al. BMC Neurol. .

Abstract

Background: Neuroregeneration is a relatively recent concept that includes neurogenesis, neuroplasticity, and neurorestoration--implantation of viable cells as a therapeutical approach.

Discussion: Neurogenesis and neuroplasticity are impaired in brains of patients suffering from Alzheimer's Disease or Parkinson's Disease and correlate with low endogenous protection, as a result of a diminished growth factors expression. However, we hypothesize that the brain possesses, at least in early and medium stages of disease, a "neuroregenerative reserve", that could be exploited by growth factors or stem cells-neurorestoration therapies.

Summary: In this paper we review the current data regarding all three aspects of neuroregeneration in Alzheimer's Disease and Parkinson's Disease.

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Figures

Figure 1
Figure 1
The large concept of neuroregeneration contains three landmarks: endogenous protection by growth factors, neurogenesis and neurorestoration. Rather than perceiving them as isolated events, they should be viewed interrelated, one creating the premises for generating the other.
See this image and copyright information in PMC

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