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Review
. 2011 Nov;8(11):1804-8.
doi: 10.1016/j.hrthm.2011.06.012. Epub 2011 Jun 12.

Arrhythmia triggers in heart failure: the smoking gun of [Ca2+]i dysregulation

Gary L Aistrup  1 , C William Balke, J Andrew Wasserstrom
Affiliations
Review

Arrhythmia triggers in heart failure: the smoking gun of [Ca2+]i dysregulation

Gary L Aistrup et al. Heart Rhythm. 2011 Nov.

Abstract

Among the most serious problems associated with heart failure is the increased likelihood of life-threatening arrhythmias. Both triggered and reentrant arrhythmias in heart failure may arise as a result of aberrant intracellular Ca cycling. This article presents some new ideas, based on recent studies, about how altered Ca cycling in heart failure might serve as the cellular basis for arrhythmogenesis.

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