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Case Reports
. 1990 Oct 15;49(2):177-84.
doi: 10.1016/0165-4608(90)90140-6.

Are some cases of acute leukemia with t(8;21) hybrid leukemias?

G X Sun  1 , R S Sparkes, S Wormsley, F Naeim, R Champlin, R P Gale
Affiliations
Case Reports

Are some cases of acute leukemia with t(8;21) hybrid leukemias?

G X Sun et al. Cancer Genet Cytogenet. .

Abstract

Translocations between chromosomes 8 and 21, t(8;21)(q22;q22), occur most commonly in acute myelogenous leukemia (AML) of the M2 FAB type. We studied two cases of acute leukemia with t(8;21) by immune phenotyping and IgH and T-cell receptor beta chain gene rearrangement analyses. These cases had increased blasts in bone marrow (greater than 50%). Auer rods, and evidence of granulocyte maturation. Blasts from both cases expressed CD19(B4), a B-cell antigen, as well as myeloid antigens including CD13(My7) and CD33(My9). HLA-DR, CD34, and TdT were also strongly positive. IgH or TCR beta gene rearrangements were not detected. We suggest that some cases of acute leukemia with t(8;21) may be hybrid leukemias with transformation in a multipotent stem cell.

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