"Going KiNativ": probing the Native Kinome
- PMID: 21700204
- DOI: 10.1016/j.chembiol.2011.06.001
"Going KiNativ": probing the Native Kinome
Abstract
In this issue, Patricelli et al. (2011) describe an in situ chemoproteomics approach (KiNativ™) for profiling the kinome and kinome response to specific kinase inhibitors that enables characterization of inhibitor interactions with endogenously expressed kinases in native conditions.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Comment on
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In situ kinase profiling reveals functionally relevant properties of native kinases.Chem Biol. 2011 Jun 24;18(6):699-710. doi: 10.1016/j.chembiol.2011.04.011. Chem Biol. 2011. PMID: 21700206 Free PMC article.
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