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. 2011 Sep;26(9):1126-30.
doi: 10.1177/0883073811408092. Epub 2011 Jun 23.

Hypothermia is correlated with seizure absence in perinatal stroke

Mary J Harbert  1 , Emily W Y Tam, Hannah C Glass, Sonia L Bonifacio, Laurel A Haeusslein, A James Barkovich, Rita J Jeremy, Elizabeth E Rogers, David V Glidden, Donna M Ferriero
Affiliations

Hypothermia is correlated with seizure absence in perinatal stroke

Mary J Harbert et al. J Child Neurol. 2011 Sep.

Abstract

Within a single-center prospective cohort study of neonatal encephalopathy involving 315 subjects, 15 neonates were found to have a focal stroke on magnetic resonance imaging. These 15 patients were matched on the basis of gender and degree of encephalopathy to 30 neonates without stroke from the same cohort. On Bayley Scales of Infant Development, the stroke group had Mental Development Index scores that were 1.7 standard deviations lower compared with controls (P = .007). This association was no longer seen after adjustment for the presence of neonatal seizures (P = .11). Of the 15 patients with stroke, 5 had been treated with hypothermia. None of these 5 had seizures in the neonatal period, compared with 7 of the untreated 10. This is the first human study to demonstrate a potential treatment effect of therapeutic hypothermia on perinatal stroke. It was also shown that seizures are associated with worse cognitive outcomes for stroke that presents with encephalopathy.

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Figures

Figure 1
Figure 1
Bayley MDI scores at 30 months after neonatal encephalopathy with (n=5) and without (n=11) focal stroke on MRI. The boxplot shows the median as a white line, the 25th and 75th percentiles in the shaded box, and the 5th and 95th percentiles in the whiskers. Any outliers are plotted outside the whiskers (none).
See this image and copyright information in PMC

References

    1. Lynch JK, Hirtz DG, DeVeber G, Nelson KB. Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics. 2002;109:116–23. - PubMed
    1. Cowan F, Rutherford M, Groenendaal F, et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet. 2003;361:736–42. - PubMed
    1. Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2007:CD003311. - PubMed
    1. Hemmen TM, Raman R, Guluma KZ, et al. Intravenous thrombolysis plus hypothermia for acute treatment of ischemic stroke (ICTuS-L): final results. Stroke. 2010;41:2265–70. - PMC - PubMed
    1. van der Worp HB, Sena ES, Donnan GA, Howells DW, Macleod MR. Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain. 2007;130:3063–74. - PubMed

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