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. 2011;76(2):123-9.
doi: 10.1159/000327852. Epub 2011 Jun 22.

Relationship between cardiovascular risk factors and adipokines in adolescents

Daniela A Rubin  1 , Robert G McMurray, Anthony C Hackney, Joanne S Harrell
Affiliations

Relationship between cardiovascular risk factors and adipokines in adolescents

Daniela A Rubin et al. Horm Res Paediatr. 2011.

Abstract

This study evaluated the associations of adipokines with cardiovascular risk factors.

Subjects/methods: 60 normal weight (BMI ≤75th percentile) and 60 overweight (BMI ≥95th percentile) adolescents aged 10-14 years. Resting systolic and diastolic blood pressures (SBP, DBP) and waist circumference were obtained in duplicate. Circulating adiponectin, resistin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), total cholesterol (TC), high-density lipoprotein (HDL), and triglycerides (TG) were measured from fasting plasma samples.

Results: Simple correlations showed that SBP was significantly related (p < 0.05) to adiponectin (r = -0.185), resistin (r = 0.207), and IL-6 (r = 0.238); HDL was significantly related to adiponectin (r = 0.398) and TNF-α (r = -0.227). TG was only related to adiponectin (r = -0.292, p < 0.05). Multiple regression models controlling for puberty and ethnicity indicated that adiponectin (R(2) = 0.152, p < 0.05), resistin (R(2) = 0.152, p < 0.05), and IL-6 (R(2) = 0.170, p < 0.05) were associated with SBP. The association between adiponectin and HDL was stronger in normal weight versus overweight adolescents (R(2) = 0.336, p < 0.05). None of the other models showed differences in the associations by weight status.

Conclusions: In adolescents, SBP but not DBP was associated with most adipokines. HDL, but not TC, was also associated with some adipokines. TG were only associated with adiponectin. Associations were mostly related to adiposity.

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References

    1. Reaven GM. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607. - PubMed
    1. Sinaiko AR, Steinberger J, Moran A, Hong CP, Prineas RJ, Jacobs DR., Jr Influence of insulin resistance and body mass index at age 13 on systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19. Hypertension. 2006;48:730–736. - PubMed
    1. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004;350:2362–2374. - PubMed
    1. Williams DE, Cadwell BL, Cheng YJ, Cowie CC, Gregg EW, Geiss LS, Engelgau MM, Narayan KM, Imperatore G. Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999–2000. Pediatrics. 2005;116:1122–1126. - PubMed
    1. Van Gaal LF, Mertens IL, Block CD. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:875–880. - PubMed

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