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Review
. 2011 Jun 24;11(7):503-11.
doi: 10.1038/nrc3057.

Pro-senescence therapy for cancer treatment

Caterina Nardella  1 , John G Clohessy, Andrea Alimonti, Pier Paolo Pandolfi
Affiliations
Review

Pro-senescence therapy for cancer treatment

Caterina Nardella et al. Nat Rev Cancer. .

Abstract

Abundant evidence points to a crucial physiological role for cellular senescence in combating tumorigenesis. Thus, the engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. In this Opinion article, we focus on concepts that are relevant to a pro-senescence approach to therapy and we propose potential therapeutic strategies that aim to enhance the pro-senescence response in tumours.

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