doi: 10.1016/0378-1097(90)90074-z.
Inhibition of peptidoglycan biosynthesis in Bacillus megaterium by daptomycin
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- PMID: 2170230
- DOI: 10.1016/0378-1097(90)90074-z
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Inhibition of peptidoglycan biosynthesis in Bacillus megaterium by daptomycin
FEMS Microbiol Lett.
.
Abstract
The effects of daptomycin on exponential phase cells of Bacillus megaterium were investigated. Bacteriostasis was observed for concentrations between 1 and 3 micrograms/ml and maximal rate of cell lysis at 10 micrograms/ml. At sublytic concentrations (1.5-3 micrograms/ml), the variations of the pools of UDP-N-acetylglucosamine and UDP-N-acetylmuramyl-pentapeptide, as well as the incorporation of (14C)-N-acetylglucosamine into peptidoglycan were studied. From the results it was concluded that the lethal target of daptomycin could be a metabolic step between glucosamine 6-phosphate and UDP-N-acetylglucosamine.
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