[Intelligence quotient related with congenital hypotyroidism etiology]

Abstract

Background: In Mexico, the congenital hypothyroidism (CH) is a public health problem that has a national incidence ranging from 1:1951 to 1:2458 live births. It is the main endocrine cause of mental retardation. The objective was to evaluate the intelligence coefficient (IQ) of patients with CH using the Wechsler Scale (WS) and to correlate the degree of involvement with its etiology.

Methods: We included patients with CH diagnosed by neonatal screening and treated by who attended the test of Wechsler. Data were obtained from the clinical records. Statistical descriptive were used.

Results: We included 15 male (21.7%) and 54 females (78.3%) patients. According to the dysgenesis aetiology was secondary in 51 patients (89.9%) and different from dysgenesis in 18 (26.1%). The age at diagnosis was 12.4 days. The initial replacement dose was 10-5 mg/kg/day. The average age at time of psychometric assessment was 6.4 years. The severity of hypothyroidism was 29 mild, 26 moderate and 14 severe. The mean IQ was 99.47. There was no relationship between IQ and the severity of hypothyroidism (p=0.31), age of initiation of treatment (p=0.271) and etiology (p=0.127).

Conclusions: No relationship was found between the etiology nor the severity of CH with IQ.