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Comment
. 2011 Jun 24;145(7):1007-9.
doi: 10.1016/j.cell.2011.06.002.

Stuck in the middle: drugging the ubiquitin system at the e2 step

J Wade Harper  1 , Randall W King
Affiliations
Free article
Comment

Stuck in the middle: drugging the ubiquitin system at the e2 step

J Wade Harper et al. Cell. .
Free article

Abstract

The discovery of a small-molecule allosteric inhibitor of the CDC34 ubiquitin-conjugating enzyme (E2) by Ceccarelli et al. raises the possibility that it will be generally feasible to selectively inhibit ubiquitin transfer at this central step in the ubiquitin pathway.

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  • An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.
    Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F. Ceccarelli DF, et al. Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16. Cell. 2011. PMID: 21683433

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