Lymphocyte signaling converges on microtubules
- PMID: 21703536
- DOI: 10.1016/j.immuni.2011.06.004
Lymphocyte signaling converges on microtubules
Abstract
Movement of immunoreceptor microclusters tunes lymphocyte activation, but the underlying mechanisms are incompletely understood. In this issue of Immunity, Schnyder et al. (2011) and Hashimoto-Tane et al. (2011) show that cytoplasmic dynein drives microcluster centralization along microtubules.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.Immunity. 2011 Jun 24;34(6):905-18. doi: 10.1016/j.immuni.2011.06.001. Immunity. 2011. PMID: 21703542
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Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation.Immunity. 2011 Jun 24;34(6):919-31. doi: 10.1016/j.immuni.2011.05.012. Immunity. 2011. PMID: 21703543
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