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Review
. 2011 Jun;3(6 Suppl 1):S73-7.
doi: 10.1016/j.pmrj.2011.02.019.

Biological basis of exercise-based treatments: spinal cord injury

D Michele Basso  1 , Christopher N Hansen
Affiliations
Review

Biological basis of exercise-based treatments: spinal cord injury

D Michele Basso et al. PM R. 2011 Jun.

Abstract

Despite intensive neurorehabilitation, extensive functional recovery after spinal cord injury is unattainable for most individuals. Optimal recovery will likely depend on activity-based, task-specific training that personalizes the timing of intervention with the severity of injury. Exercise paradigms elicit both beneficial and deleterious biophysical effects after spinal cord injury. Modulating the type, intensity, complexity, and timing of training may minimize risk and induce greater recovery. This review discusses the following: (a) the biological underpinning of training paradigms that promote motor relearning and recovery, and (b) how exercise interacts with cellular cascades after spinal cord injury. Clinical implications are discussed throughout.

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Figure 1
Figure 1
Optimal activity-based rehabilitation emerges at the intersection of task specificity, and appropriately timed delivery of training according to the severity of the spinal cord injury.
See this image and copyright information in PMC

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