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Randomized Controlled Trial
. 2011 Jun 30;95(8):2595-8.e1-6.
doi: 10.1016/j.fertnstert.2011.05.048.

Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study

Gwinnett Ladson  1 , William C Dodson, Stephanie D Sweet, Anthony E Archibong, Allen R Kunselman, Laurence M Demers, Peter A Lee, Nancy I Williams, Ponjola Coney, Richard S Legro
Affiliations
Randomized Controlled Trial

Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study

Gwinnett Ladson et al. Fertil Steril. .

Abstract

Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life.

Trial registration: ClinicalTrials.gov NCT00151411.

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Figures

FIGURE 1
FIGURE 1
(A) Changes in total serum testosterone, (B) Free Androgen Index (FAI), (C) acne lesion count, and (D) weight over 6 months by treatment arm. Metformin = combined metformin and lifestyle; Placebo = lifestyle and metformin. *P<.05 for a within-group change from baseline, †P<.05 for a between-group comparison at a given month.
See this image and copyright information in PMC

References

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