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. 2011 Sep;55(9):4394-7.
doi: 10.1128/AAC.00833-10. Epub 2011 Jun 27.

In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions

Will Stubbings  1 , Pamela Leow, Goh Chee Yong, Falicia Goh, Barbara Körber-Irrgang, Michael Kresken, Rainer Endermann, Harald Labischinski
Affiliations

In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions

Will Stubbings et al. Antimicrob Agents Chemother. 2011 Sep.

Abstract

Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were 4- to 8-fold lower than those determined at neutral pH. These observations were then confirmed against a larger collection of bacteria. These data suggest that finafloxacin could potentially offer a therapeutic advantage within acidic foci of infection.

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Figures

Fig. 1.
Fig. 1.
MICs of finafloxacin, ciprofloxacin, and levofloxacin at pH values of 7.4 and below. Key: ▾, finafloxacin; □, ciprofloxacin; ▵, levofloxacin.
See this image and copyright information in PMC

References

    1. Byerly T. C. 1953. Handbook of biological data. Science 118:3.
    1. Clinical and Laboratory Standards Institute 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed Approved standard M07–A7. Clinical and Laboratory Standards Institute, Wayne, PA
    1. Clinical and Laboratory Standards Institute 2007. Performance standards for antimicrobial susceptibility testing; 17th informational supplement. Document M100–S17. Clinical and Laboratory Standards Institute, Wayne, PA
    1. Dalhoff A., Schubert S., Ullmann U. 2005. Effect of pH on the in vitro activity of and propensity for emergence of resistance to fluoroquinolones, macrolides, and a ketolide. Infection 33(Suppl. 2):36–43 - PubMed
    1. Dalhoff A., Stubbings W., Schubert S. 2011. Comparative in vitro activities of the novel antibacterial finafloxacin against selected Gram-positive and Gram-negative bacteria tested in Mueller-Hinton broth and synthetic urine. Antimicrob. Agents Chemother. 55:1814–1818 - PMC - PubMed

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