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. 2011 Sep;55(9):4408-11.
doi: 10.1128/AAC.00555-11. Epub 2011 Jun 27.

Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex

Michaela Projahn  1 , Claudio U Köser, Susanne Homolka, David K Summers, John A C Archer, Stefan Niemann
Affiliations

Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex

Michaela Projahn et al. Antimicrob Agents Chemother. 2011 Sep.

Abstract

Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.

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