Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jul;60(7):1849-55.
doi: 10.2337/db11-0400.

Maternal environment and the transgenerational cycle of obesity and diabetes

Dana Dabelea  1 , Tessa Crume
Affiliations
Review

Maternal environment and the transgenerational cycle of obesity and diabetes

Dana Dabelea et al. Diabetes. 2011 Jul.
No abstract available

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Mean BMI curves for youth both exposed and unexposed to maternal diabetes in utero from 27 months of age to 13 years, adjusted for sex and race/ethnicity. From Crume et al., J Pediatrics 2011 (9), with permission.
FIG. 2.
FIG. 2.
Mean BMI curves for youth both exposed and unexposed to maternal diabetes in utero from birth to 26 months of age, adjusted for sex and race/ethnicity. From Crume et al., J Pediatrics 2011 (9), with permission.
FIG. 3.
FIG. 3.
Potential pathways linking fetal overnutrition to long-term consequences in the offspring. Modified from McMillen, Reproduction 2006 (40), with permission.
FIG. 4.
FIG. 4.
The vicious cycle of diabetes and obesity.
See this image and copyright information in PMC

References

    1. Gluckman PD, Hanson MA. Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective. Int J Obes (Lond) 2008;32(Suppl. 7):S62–S71 - PubMed
    1. Freinkel N. Banting Lecture 1980. Of pregnancy and progeny. Diabetes 1980;29:1023–1035 [review] - PubMed
    1. Pettitt DJ, Knowler WC. Diabetes and obesity in the Pima Indians: a crossgenerational vicious cycle. J Obesity Weight Regul 1988;7:61–65
    1. Pettitt DJ, Nelson RG, Saad MF, Bennett PH, Knowler WC. Diabetes and obesity in the offspring of Pima Indian women with diabetes during pregnancy. Diabetes Care 1993;16:310–314 - PubMed
    1. Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glucose tolerance in adolescent offspring of diabetic mothers: relationship to fetal hyperinsulinism. Diabetes Care 1995;18:611–617 - PubMed