doi: 10.1039/c1cc12778k.
Epub 2011 Jun 27.
Chiral N-heterocyclic carbene catalyzed annulation of α,β-unsaturated aldehydes with 1,3-dicarbonyls
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- PMID: 21709880
- DOI: 10.1039/c1cc12778k
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Chiral N-heterocyclic carbene catalyzed annulation of α,β-unsaturated aldehydes with 1,3-dicarbonyls
Chem Commun (Camb).
.
Abstract
Chiral N-heterocyclic carbene catalyzed annulations of ynals and enals with 1,3-dicarbonyls have been described. The two reactions provided direct and efficient methods for enantioselective synthesis of functionalized dihydropyranones. Comparatively, the reactions starting from ynals were atom-economical; furthermore the reactions of enals demonstrated broader substrate compatibility.
This journal is © The Royal Society of Chemistry 2011
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