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. 2012 Jan;68(1):67-74.
doi: 10.1002/ps.2222. Epub 2011 Jun 24.

Effect of amphotericin B nanodisks on plant fungal diseases

Alejandro Pérez-de-Luque  1 , Zuny Cifuentes, Jennifer A Beckstead, Josefina C Sillero, Carmen Avila, Josefa Rubio, Robert O Ryan
Affiliations

Effect of amphotericin B nanodisks on plant fungal diseases

Alejandro Pérez-de-Luque et al. Pest Manag Sci. 2012 Jan.

Abstract

Background: The development of water-soluble nanodevices extends the potential use of compounds developed for other purposes (e.g. antifungal drugs or antibiotics) for applications in agriculture. For example, the broad-spectrum, water-insoluble, macrolide polyene antibiotic amphotericin B (AMB) could be used to inhibit phytopathogenic fungi. A new formulation embedding AMB in nanodisks (NDs) enhances antibiotic solubility and confers protection against environmental damage. In the present study, AMB-NDs were tested for efficacy against several phytopathogenic fungi in vitro and on infected living plants (chickpea and wheat).

Results: Compared with AMB in dimethylsulfoxide (DMSO), AMB-NDs increased the sensitivity of several fungal species to this antimycotic in vitro. Sensitivity varied with fungal species as well as with the forma specialis. Phytophthora cinnamomi, previously reported as insensitive to other polyene antimycotics, remained unaffected at the doses examined. Some effect against disease symptoms were obtained with AMB-NDs against fusarium wilt in chickpea, whereas the results were highly variable in wheat, depending on both the species and treatment regimen.

Conclusion: The results confirm that formulation of AMB into ND increases its effectiveness against phytopathogenic fungi in vitro, opening the possibility for its use on infected plants in the field.

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Figures

Figure 1
Figure 1
Petri dishes showing the growth of some of the tested fungi under different treatment conditions.
Figure 2
Figure 2
Effect of AMB-ND treatment on the development of fusarium wilt disease in chickpea.
Figure 3
Figure 3
Effect of AMB-ND treatment on P. triticina disease severity on wheat plants.
See this image and copyright information in PMC

References

    1. Robinson DKR, Salejova-Zadrazilova G. [11 November 2010];Observatory NANO (2010) Nanotechnologies for Nutrient and Biocide Delivery in Agricultural Production. [Online]. Working Paper Version (April 2010). Available: http://www.observatorynano.eu/project/filesystem/files/Controlled%20deli....
    1. Wang L, Li X, Zhang G, Dong J, Eastoe J. Oil-in-water nanoemulsions for pesticide formulations. J Coll Int Sci. 2007;314:230–235. - PubMed
    1. Pérez-de-Luque A, Rubiales D. Nanotechnology for parasitic plant control. Pest Manag Sci. 2009;65:540–545. - PubMed
    1. Nair R, Varghese SH, Nair BG, Maekawa T, Yoshida Y, Kumar DS. Nanoparticulate material delivery to plants. Plant Sci. 2010;179:154–163.
    1. Tsuji K. Microencapsulation of pesticides and their improved handling safety. J Microencapsul. 2001;18:137–147. - PubMed

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