Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2011 Jul 1;17(13):4189-91.
doi: 10.1158/1078-0432.CCR-11-0841. Epub 2011 Jun 28.

Getting personal with melanoma

Helen Heslop  1
Affiliations
Comment

Getting personal with melanoma

Helen Heslop. Clin Cancer Res. .

Abstract

Long-term follow-up of patients with metastatic melanoma who received adoptive immunotherapy with autologous tumor infiltrating lymphocytes shows that patients who attained complete remission had durable responses, with 19 of 20 such patients remaining in remission from 3 to 7 years or more.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 1 shows T cell therapies targeting melanoma. Tumor may be harvested and tumor infiltrating lymphocytes harvested and cultured for subsequent infusion to the patient (1A). Peripheral blood mononuclear cells may be genetically modified with a chimeric antigen receptor (shown) or a T cell receptors specific for an antigen expressed by tumor cells (1B). Peripheral blood mononuclear cells may be stimulated with peptides derived from a tumor antigen expressed on antigen presenting cells to generate T cell clones which recognize tumor antigens (1C)
Figure 1
Figure 1
Figure 1 shows T cell therapies targeting melanoma. Tumor may be harvested and tumor infiltrating lymphocytes harvested and cultured for subsequent infusion to the patient (1A). Peripheral blood mononuclear cells may be genetically modified with a chimeric antigen receptor (shown) or a T cell receptors specific for an antigen expressed by tumor cells (1B). Peripheral blood mononuclear cells may be stimulated with peptides derived from a tumor antigen expressed on antigen presenting cells to generate T cell clones which recognize tumor antigens (1C)
Figure 1
Figure 1
Figure 1 shows T cell therapies targeting melanoma. Tumor may be harvested and tumor infiltrating lymphocytes harvested and cultured for subsequent infusion to the patient (1A). Peripheral blood mononuclear cells may be genetically modified with a chimeric antigen receptor (shown) or a T cell receptors specific for an antigen expressed by tumor cells (1B). Peripheral blood mononuclear cells may be stimulated with peptides derived from a tumor antigen expressed on antigen presenting cells to generate T cell clones which recognize tumor antigens (1C)
See this image and copyright information in PMC

Comment on

References

    1. Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, et al. Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T Cell Transfer Immunotherapy. Clin Cancer Res. 2011 April 15; 10.1158/1078-432.CCR-11-0116. - PMC - PubMed
    1. Kolb HJ. Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood. 2008;112(12):4371–83. - PubMed
    1. Heslop HE, Slobod KS, Pule MA, Hale GA, Rousseau A, Smith CA, et al. Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood. 2010;115(5):925–35. - PMC - PubMed
    1. Louis CU, Straathof K, Bollard CM, Ennamuri S, Gerken C, Lopez TT, et al. Adoptive transfer of EBV-specific T cells results in sustained clinical responses in patients with locoregional nasopharyngeal carcinoma. J Immunother. 2010;33(9):983–90. - PMC - PubMed
    1. O’Reilly RJ, Doubrovina E, Trivedi D, Hasan A, Kollen W, Koehne G. Adoptive transfer of antigen-specific T-cells of donor type for immunotherapy of viral infections following allogeneic hematopoietic cell transplants. Immunol Res. 2007;38(1-3):237–50. - PubMed