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Comparative Study
. 1990 Oct;163(4 Pt 1):1164-7.
doi: 10.1016/0002-9378(90)90680-6.

The prognostic significance of CA 125 half-life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoreduction

V J Hunter  1 , L Daly, M Helms, J T Soper, A Berchuck, D L Clarke-Pearson, R C Bast Jr
Affiliations
Comparative Study

The prognostic significance of CA 125 half-life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoreduction

V J Hunter et al. Am J Obstet Gynecol. 1990 Oct.

Abstract

Fifty-four patients with advanced epithelial ovarian cancer were monitored with serial serum CA 125 levels after surgical cytoreduction and during multi-agent chemotherapy with cisplatin-containing regimens. CA 125 half-life of less than 20 days was associated with prolonged overall survival (p less than 0.015). In those patients who eventually were found to be disease-free at surgical surveillance procedures, normalization of serum CA 125 levels to less than 35 U/ml within 65 days of primary operation also suggested an improved survival (p less than 0.059).

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