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Review
. 2011:716:14-28.
doi: 10.1007/978-1-4419-9533-9_2.

Mast cell progenitor trafficking and maturation

Jenny Hallgren  1 , Michael F Gurish
Affiliations
Review

Mast cell progenitor trafficking and maturation

Jenny Hallgren et al. Adv Exp Med Biol. 2011.

Abstract

Mast cells are derived from the hematopoietic progenitors found in bone marrow and spleen. Committed mast cell progenitors are rare in bone marrow suggesting they are rapidly released into the blood where they circulate and move out into the peripheral tissues. This migration is controlled in a tissue specific manner. Basal trafficking to the intestine requires expression of α4β7 integrin and the chemokine receptor CXCR2 by the mast cell progenitors and expression of MAdCAM-1 and VCAM-1 in the intestinal endothelium; and is also controlled by dendritic cells expressing the transcriptional regulatory protein T-bet. None of these play a role in basal trafficking to the lung. With the induction of allergic inflammation in the lung, there is marked recruitment of committed mast cell progenitors to lung and these cells must express α4β7 and α4β1 integrins. Within the lung there is a requirement for expression of VCAM-1 on the endothelium that is regulated by CXCR2, also expressed on the endothelium. There is a further requirement for expression of the CCR2/CCL2 pathways for full recruitment of the mast cell progenitors to the antigen-inflamed lung.

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Figures

Figure 1
Figure 1
Development of committed mast cell progenitors (MCp) in the bone marrow (BM) from the hematopoietic stem cell (HSC) and the molecules identified as playing a role in the trafficking of the these cells to the intestine and peritoneal cavity under basal, non-inflamed conditions. Two different developmental pathways have been proposed leading to the production of committed mast cell progenitors. These cells then move out to peripheral tissues via the circulation and migrate into the specific tissue sites such as the intestine and serosal cavity under the control of specific molecules such as the α4 integrins and various chemokine pathways. A role for the C3b and TPO receptors has been shown to affect mast cell numbers in the skin and peritoneal cavity. See text for details.
Figure 2
Figure 2
Identification of the molecules and cells controlling (or perhaps controlling, e.g., LTB4, PGE2) inflammation-induced recruitment of MCp to the lung in BALB/c mice and influencing their maturation to mature mucosal mast cells. Question marks indicate pathways not confirmed or established in vivo. See text for details.
See this image and copyright information in PMC

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