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Clinical Trial
. 2012 Jan 15;118(2):444-51.
doi: 10.1002/cncr.26277. Epub 2011 Jun 28.

A prospective phase 2 study of surgery followed by chemotherapy and radiation for superior sulcus tumors

Daniel R Gomez  1 , James D Cox, Jack A Roth, Pamela K Allen, Xiong Wei, Reza J Mehran, Jae Y Kim, Stephen G Swisher, David C Rice, Ritsuko Komaki
Affiliations
Clinical Trial

A prospective phase 2 study of surgery followed by chemotherapy and radiation for superior sulcus tumors

Daniel R Gomez et al. Cancer. .

Abstract

Background: The optimal treatment for locally advanced superior sulcus tumors is not clear. The authors report long-term results of a trial examining the safety and efficacy of surgery followed by concurrent chemoradiation therapy for this disease.

Methods: Thirty-two patients with resectable or marginally resectable superior sulcus tumors at The University of Texas MD Anderson Cancer Center from 1994 to 2010 were enrolled in a prospective trial. Surgery involved segmentectomy or lobectomy with en bloc resection of the involved chest wall and complete nodal staging; radiation therapy (RT) began 14 to 42 days later to a dose of 60 grays (Gy) in 50 1.2-Gy fractions if surgical margins were negative or 64.8 Gy in 54 1.2-Gy fractions if margins were positive. Two cycles of etoposide (50 mg/m(2) ) and cisplatin (50 mg/m(2) ) were given during RT, and another 3 cycles were given after RT. Eleven patients underwent prophylactic cranial irradiation (PCI).

Results: The protocol completion rate was 78%. Gross total resection was accomplished in all 32 patients; 28% underwent R1 resection. Operative mortality was 0%. The most common surgical complication was postoperative pneumonia (25%). At a median follow-up time of 53.4 months (range, 2-154 months), the 2-year, 5-year, and 10-year rates of locoregional control were 84%, 76%, and 76%; distant metastasis-free survival, 52%, 48%, and 48%; disease-free survival, 49%, 45%, and 45%; and overall survival, 72%, 50%, and 45%, respectively. The brain was the most common site of distant failure (n = 5), but no patient who received PCI experienced brain metastasis.

Conclusions: Surgery followed by postoperative chemoradiation is safe and effective for the treatment of marginally resectable superior sulcus tumors.

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Conflict of interest statement

CONFLICT OF INTEREST DISCLOSURES

The authors made no disclosures.

Figures

Figure 1
Figure 1
Kaplan-Meier curves illustrate overall survival (OS), disease-free survival (DFS), locoregional tumor control (LRC), and distant metastasis-free survival (DMFS).
See this image and copyright information in PMC

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