Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:2011:943216.
doi: 10.4061/2011/943216. Epub 2011 Jun 13.

Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?

Eduardo Mansilla  1 , Vanina Díaz Aquino, Daniel Zambón, Gustavo Horacio Marin, Karina Mártire, Gustavo Roque, Thomas Ichim, Neil H Riordan, Amit Patel, Flavio Sturla, Gustavo Larsen, Rubén Spretz, Luis Núñez, Carlos Soratti, Ricardo Ibar, Michiel van Leeuwen, José María Tau, Hugo Drago, Alberto Maceira
Affiliations

Could metabolic syndrome, lipodystrophy, and aging be mesenchymal stem cell exhaustion syndromes?

Eduardo Mansilla et al. Stem Cells Int. 2011.

Abstract

One of the most important and complex diseases of modern society is metabolic syndrome. This syndrome has not been completely understood, and therefore an effective treatment is not available yet. We propose a possible stem cell mechanism involved in the development of metabolic syndrome. This way of thinking lets us consider also other significant pathologies that could have similar etiopathogenic pathways, like lipodystrophic syndromes, progeria, and aging. All these clinical situations could be the consequence of a progressive and persistent stem cell exhaustion syndrome (SCES). The main outcome of this SCES would be an irreversible loss of the effective regenerative mesenchymal stem cells (MSCs) pools. In this way, the normal repairing capacities of the organism could become inefficient. Our point of view could open the possibility for a new strategy of treatment in metabolic syndrome, lipodystrophic syndromes, progeria, and even aging: stem cell therapies.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Lipodistrophic syndromes.
Figure 2
Figure 2
Stem cell exhaustion syndrome hypothesis.
Figure 3
Figure 3
Mesenchymal stem cells pools as a coordinated network.
Figure 4
Figure 4
Metabolic syndrome in obesity and lipodistrophy.
Figure 5
Figure 5
Pathologies propably caused by a stem cell exhaustion syndrome.
See this image and copyright information in PMC

References

    1. Saito I, Iso H, Kokubo Y, Inoue M, Tsugane S. Metabolic syndrome and all-cause and cardiovascular disease mortality: Japan Public Health Center-based Prospective (JPHC) Study. Circulation Journal. 2009;73(5):878–884. - PubMed
    1. Zimmet P, Alberti G. The metabolic syndrome: progress towards one definition for an epidemic of our time. Nature Clinical Practice Endocrinology and Metabolism. 2008;4(5):p. 239. - PubMed
    1. Reaven GM. The metabolic syndrome: requiescat in Pace. Clinical Chemistry. 2005;51(6):931–938. - PubMed
    1. Pappolla MA, Bryant-Thomas TK, Herbert D, et al. Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology. 2003;61(2):199–205. - PubMed
    1. Junyent M, Gilabert R, Jarauta E, et al. Impact of low-density lipoprotein receptor mutational class on carotid atherosclerosis in patients with familial hypercholesterolemia. Atherosclerosis. 2010;208(2):437–441. - PubMed

LinkOut - more resources