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. 2012:2012:981896.
doi: 10.1155/2012/981896. Epub 2011 Jun 12.

Effects of encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus rats

Yajing Li  1 , Minli Chen, Hongzhuan Xuan, Fuliang Hu
Affiliations

Effects of encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus rats

Yajing Li et al. Evid Based Complement Alternat Med. 2012.

Abstract

The present study investigates the encapsulated propolis on blood glycemic control, lipid metabolism, and insulin resistance in type 2 diabetes mellitus (T2DM) rats. The animal characteristics and biological assays of body weight, fasting blood glucose (FBG), fasting serum insulin (FINS), insulin act index (IAI), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured and euglycemic hyperinsulinemic glucose clamp technique were used to determine these effects. Our findings show that oral administration of encapsulated propolis can significantly inhibit the increasing of FBG and TG in T2DM rats and can improve IAI and M value in euglycemic hyperinsulinemic clamp experiment. There was no significant effects on body weight, TC, HDL-C, and LDL-C in T2DM rats treated with encapsulated propolis. In conclusion, the results indicate that encapsulated propolis can control blood glucose, modulate lipid metabolism, and improve the insulin sensitivity in T2DM rats.

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Figures

Figure 1
Figure 1
Effect of encapsulated propolis treatment on body weight in T2DM Rats. Values are expressed as the means (standard deviations not shown).
Figure 2
Figure 2
Insulin sensitivity in the normal control and T2DM rats treated with or without encapsulated propolis (100 mg/kg·d) for 6 days. Values are expressed as the means ± standard deviations.
See this image and copyright information in PMC

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