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. 2011:2011:438056.
doi: 10.1155/2011/438056. Epub 2011 May 26.

Practices in wound healing studies of plants

Rupesh Thakur  1 , Nitika Jain, Raghvendra Pathak, Sardul Singh Sandhu
Affiliations

Practices in wound healing studies of plants

Rupesh Thakur et al. Evid Based Complement Alternat Med. 2011.

Abstract

Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Various plant products have been used in treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Phytoconstituents derived from plants need to be identified and screened for antimicrobial activity for management of wounds. The in vitro assays are useful, quick, and relatively inexpensive. Small animals provide a multitude of model choices for various human wound conditions. The study must be conducted after obtaining approval of the Ethics Committee and according to the guidelines for care and use of animals. The prepared formulations of herbal extract can be evaluated by various physicopharmaceutical parameters. The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts.

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Figures

Figure 1
Figure 1
Schematic illustration of practices in wound healing studies of plants.
Figure 2
Figure 2
Percentage utilization of different methods of phytoconstituent extraction, calculated from the published research articles.
Figure 3
Figure 3
Percentage utilization of different techniques for in vitro studies, calculated from the published research articles.
Figure 4
Figure 4
Percentage utilization of different wound models for in vivo studies, calculated from the published research articles.
Figure 5
Figure 5
Percentage utilization of different animals for in vivo studies, calculated from the published research articles.
See this image and copyright information in PMC

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