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. 2011 Jan;27(1):110-20.
doi: 10.4103/0970-1591.78436.

Genetic and epigenetic factors: Role in male infertility

M B Shamsi  1 , K Kumar, R Dada
Affiliations

Genetic and epigenetic factors: Role in male infertility

M B Shamsi et al. Indian J Urol. 2011 Jan.

Abstract

Genetic factors contribute upto 15%-30% cases of male infertility. Formation of spermatozoa occurs in a sequential manner with mitotic, meiotic, and postmeiotic differentiation phases each of which is controlled by an intricate genetic program. Genes control a variety of physiologic processes, such as hypothalamus-pituitary-gonadal axis, germ cell development, and differentiation. In the era of assisted reproduction technology, it is important to understand the genetic basis of infertility to provide maximum adapted therapeutics and counseling to the couple.

Keywords: Azoospermia; DNA damage; Y chromosome; cytogenetic; epigenetics; infertility; mRNA; mtDNA; oligozoospermia.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
G-banded karyotype showing 47,XXY chromosomal complement (Klinefelter syndrome)
Figure 2
Figure 2
(a) Schematic illustration of Robertsonian translocation; (b) G-banded karyotype showing 45,XY t (13;14) chromosomal complement
Figure 3
Figure 3
Schematic representation showing human Y chromosome showing pseudoautosomal (PAR I and PAR II) and nonrecombining regions (MSY)
See this image and copyright information in PMC

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