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. 2011 Aug;59(8):1484-9.
doi: 10.1111/j.1532-5415.2011.03490.x. Epub 2011 Jun 30.

White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: the Honolulu-Asia aging study

Michiko Inaba  1 , Lon White, Christina Bell, Randi Chen, Helen Petrovitch, Lenore Launer, Robert D Abbott, G Webster Ross, Kamal Masaki
Affiliations

White matter lesions on brain magnetic resonance imaging scan and 5-year cognitive decline: the Honolulu-Asia aging study

Michiko Inaba et al. J Am Geriatr Soc. 2011 Aug.

Abstract

Objectives: To study white matter lesions (WMLs) and 5-year cognitive decline in elderly Japanese-American men.

Design: Longitudinal cohort study.

Setting: Population-based study in Honolulu, Hawaii.

Participants: Japanese-American men aged 74 to 95 from the Honolulu-Asia Aging Study (HAAS) who were free of prevalent dementia, underwent a protocol brain MRI scan at the fifth HAAS examination (1994-1996), and returned for cognitive testing 5 years later (N=267).

Measurements: WMLs were dichotomized as present (grade 3-9, 38.2%) or absent (grade 1-2, 61.8%). Cognitive function was measured using the Cognitive Abilities Screening Instrument (CASI), and 5-year cognitive decline was defined as a drop in CASI score of 12 points or more (1 standard deviation).

Results: Men with WMLs on MRI at baseline were significantly more likely to experience cognitive decline at 5 years than those without (22.4% vs 34.4%, P=.03). Using multiple logistic regression, adjusting for age, education, apolipoprotein (Apo)E4 allele, large or small infarcts on MRI, baseline CASI score, and hypertension, those with WMLs were significantly more likely to develop 5-year cognitive decline (odds ratio=2.00, 95% confidence interval=1.10-3.65, P=.02). This association was stronger in men who were cognitively intact and free of the ApoE4 genotype and clinical stroke at baseline.

Conclusion: Presence of WMLs on MRI was significantly associated with higher odds of 5-year cognitive decline in older Japanese-American men. Presence of WMLs may help identify people at risk for developing dementia, who may benefit from early intervention.

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References

    1. Sullivan P, Pary R, Telang F, Rifai AH, Zubenko GS. Risk factors for white matter changes detected by magnetic resonance imaging in the elderly. Stroke. 1990 Oct;21(10):1424–1428. - PubMed
    1. Sarpel G, Chaudry F, Hindo W. Magnetic resonance imaging of periventricular hyperintensity in a Veterans Administration hospital population. Arch. Neurol. 1987 Jul;44(7):725–728. - PubMed
    1. Kozachuk WE, DeCarli C, Schapiro MB, Wagner EE, Rapoport SI, Horwitz B. White matter hyperintensities in dementia of Alzheimer’s type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study. Arch. Neurol. 1990 Dec;47(12):1306–1310. - PubMed
    1. Hunt AL, Orrison WW, Yeo RA, et al. Clinical significance of MRI white matter lesions in the elderly. Neurology. 1989 Nov;39(11):1470–1474. - PubMed
    1. Longstreth WT, Jr, Manolio TA, Arnold A, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996 Aug;27(8):1274–1282. - PubMed

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