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. 2011 Aug;40(4):206-13.
doi: 10.1111/j.1600-0684.2011.00484.x. Epub 2011 Jul 1.

A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques

S M Barratt-Boyes  1 , V Wijewardana
Affiliations

A divergent myeloid dendritic cell response at virus set-point predicts disease outcome in SIV-infected rhesus macaques

S M Barratt-Boyes et al. J Med Primatol. 2011 Aug.

Abstract

Background: The mechanism for loss of myeloid dendritic cells (mDCs) from the circulation in HIV-infected individuals and its relationship to disease progression is not understood.

Methods: A longitudinal analysis of the mDC response in blood and lymph nodes during the first 12 weeks of infection was performed in a cohort of SIVmac251-infected rhesus macaques with different disease outcomes.

Results: Monkeys that rapidly progressed to disease or had long-term stable infection had significant losses or increases, respectively, in blood mDCs that were inversely correlated with virus load at set-point. The loss of mDCs from progressor animals was associated with evidence of an increase in CCR7/CCL19-dependent mDC recruitment to lymph nodes and an increase in mDC apoptosis.

Conclusions: mDC recruitment to and death within inflamed lymph nodes may contribute to disease progression in SIV infection, whereas mobilization without increased recruitment to lymph nodes may promote disease control.

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Figures

Figure 1
Figure 1
Relationship between virus load and mDCs in blood in the early stages of SIV infection of monkeys with different disease outcomes.
See this image and copyright information in PMC

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