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. 2010 Apr 22:2010:1607.

Chlamydia (uncomplicated, genital)

Paddy Horner  1
Affiliations

Chlamydia (uncomplicated, genital)

Paddy Horner. BMJ Clin Evid. .

Abstract

Introduction: Genital chlamydia is the most commonly reported bacterial sexually transmitted infection (STI) in developed countries. In women, infection occurs most commonly between the ages of 16 and 19 years.

Methods and outcomes: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of antibiotic treatment for men and non-pregnant women with uncomplicated genital chlamydial infection?What are the effects of antibiotic treatment for pregnant women with uncomplicated genital chlamydial infection? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2009 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

Results: We found 24 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

Conclusions: In this systematic review we present information relating to the effectiveness and safety of the following interventions: amoxicillin, ampicillin, azithromycin, ciprofloxacin, clarithromycin, clindamycin, doxycycline, erythromycin, lymecycline, minocycline, ofloxacin, pivampicillin, rifampicin, roxithromycin, sparfloxacin, tetracycline, and trovafloxacin.

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References

    1. Holmes KK, Sparling PF, Mardh PA, et al, eds. Sexually transmitted diseases. 4th ed. New York: McGraw Hill Inc, 2008.
    1. Horner P, Boag F. 2006 UK national guideline for the management of genital tract infection with Chlamydia trachomatis. BASHH. Available at http://www.bashh.org/documents/61/61.pdf (last accessed 26 March 2010).
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