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Comparative Study
. 1990 Sep;9(9):693-7.
doi: 10.1007/BF01964275.

In vitro activity of saperconazole (R66 905) compared with amphotericin B and itraconazole against Aspergillus species

D W Denning  1 , L H Hanson, D A Stevens
Affiliations
Comparative Study

In vitro activity of saperconazole (R66 905) compared with amphotericin B and itraconazole against Aspergillus species

D W Denning et al. Eur J Clin Microbiol Infect Dis. 1990 Sep.

Erratum in

  • Eur J Clin Microbiol Infect Dis 1991 Jan;10(1):49

Abstract

Twenty isolates of aspergillus were tested against saperconazole and 16 of these against itraconazole and amphotericin B using a macrodilution broth method. For 18 (90%) of 20 isolates tested against saperconazole, MICs were less than or equal to 3.1 mg/l and for 15 (75%) of 20 isolates MFCs were less than or equal to 3.1 mg/l. For 9 (56%) of 16 isolates tested against itraconazole, MICs were less than or equal to 3.1 mg/l, and for 4 (33%) of 12 isolates MFCs were less than or equal to 3.1 mg/l. For all 16 isolates tested against amphotericin B MICs and MFCs were less than or equal to 4.0 mg/l; for 11 of 16 isolates MICs were less than or equal to 2.0 mg/l. Saperconazole appears to be highly active against Aspergillus spp. in vitro, with a bimodal distribution of MICs and MFCs.

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References

    1. Antimicrob Agents Chemother. 1984 Apr;25(4):450-4 - PubMed
    1. Antimicrob Agents Chemother. 1984 Oct;26(4):527-34 - PubMed
    1. Am J Med. 1989 Jun;86(6 Pt 2):791-800 - PubMed
    1. Antimicrob Agents Chemother. 1989 Dec;33(12):2063-8 - PubMed
    1. J Antimicrob Chemother. 1989 Oct;24(4):533-7 - PubMed

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