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. 2011 Sep;19(9):1908-11.
doi: 10.1038/oby.2011.195. Epub 2011 Jun 30.

Overweight as a prognostic factor in children with acute lymphoblastic leukemia

Cristina B Gelelete  1 , Sandra H Pereira, Alice Maria B Azevedo, Leandro S Thiago, Mariana Mundim, Marcelo G P Land, Elaine S Costa
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Overweight as a prognostic factor in children with acute lymphoblastic leukemia

Cristina B Gelelete et al. Obesity (Silver Spring). 2011 Sep.

Abstract

Our purpose was to investigate the prognostic impact of overweight/obesity in 5-year event-free survival (EFS) in a cohort of children with acute lymphoblastic leukemia (ALL). We retrospectively analyzed 181 newly diagnosed ALL children enrolled between 1990 and 2009 and treated with Berlin-Frankfurt-Munich (BFM) protocols. The majority of children in our cohort were <10 years-old. Our data clearly indicated that overweight/obesity is an independent predictor of relapse risk, mainly in the intermediate- and high-risk groups (HR) of children. These results could be explained by changes in the chemotherapy pharmacokinetics in overweight/obese patients and by the antiapoptotic effects in leukemic cells caused by adipocytes.

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