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. 2011:6:993-1003.
doi: 10.2147/IJN.S17595. Epub 2011 May 19.

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Marziyeh Jannesari  1 , Jaleh Varshosaz, Mohammad Morshed, Maedeh Zamani
Affiliations

Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs

Marziyeh Jannesari et al. Int J Nanomedicine. 2011.

Abstract

The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the first time. The morphology and average diameter of the electrospun nanofibers were investigated by scanning electron microscopy. X-ray diffraction studies indicated an amorphous distribution of the drug inside the nanofiber blend. Introducing the drug into polymeric solutions significantly decreased solution viscosities as well as nanofiber diameter. In vitro drug release evaluations showed that both the kind of polymer and the amount of drug loaded greatly affected the degree of swelling, weight loss, and initial burst and rate of drug release. Blending PVA and PVAc exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound healing applications. Also, the thickness of the blend nanofiber mats strongly influenced the initial release and rate of drug release.

Keywords: biodegradable polymers; controlled release; drug delivery; electrospun nanofibers; wound dressing.

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Figures

Figure 1
Figure 1
SEM photographs of electrospun nanofibers without drug and with 10% w/w drug loaded: A, B) PVA; C, D) PVAc; E, F) a 50:50 blend of PVA/PVAc; G, H) effect of drug loading on appearance of PVA/PVAc blend nanofiber mats. Abbreviations: CipHCl, ciprofloxacin HCl; PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
Figure 1
Figure 1
SEM photographs of electrospun nanofibers without drug and with 10% w/w drug loaded: A, B) PVA; C, D) PVAc; E, F) a 50:50 blend of PVA/PVAc; G, H) effect of drug loading on appearance of PVA/PVAc blend nanofiber mats. Abbreviations: CipHCl, ciprofloxacin HCl; PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
Figure 2
Figure 2
Effect of CipHCl on A) the diameter of nanofibers (n = 100) and B) the solution viscosity (n = 3). Abbreviations: PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
Figure 3
Figure 3
X-ray diffraction of A) CipHCl powder, B) pure 50:50 PVA/PVAc nanofiber mat, and C) 50:50 PVA/PVAc nanofiber mat loaded with 10% w/w drug. Abbreviations: CipHCl, ciprofloxacin HCl; PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
Figure 4
Figure 4
Effect of the type of polymer and/or the drug content A) on the degree of swelling (%) and B) on the weight loss (%) of PVA, PVAc and a 50:50 blend nanofiber mat, and C) effect of the thickness of blend nanofiber mats on the degree of swelling (%) (n = 3). Abbreviations: PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
Figure 5
Figure 5
Effect of drug content on release profiles of CipHCl from PVAc (32% w/v) electrospun nanofiber mats vs time (n = 3). Abbreviations: CipHCl, ciprofloxacin HCl; PVAc, polyvinyl acetate.
Figure 6
Figure 6
Effect of drug content on release profiles of CipHCl from PVA (5% w/v) electrospun nanofiber mats vs time (n = 3). Abbreviations: CipHCl, ciprofloxacin HCl; PVAc, polyvinyl acetate.
Figure 7
Figure 7
Effect of polymers blending on the release profiles of CipHCl from medicated electrospun nanofiber mats containing 10% w/w CipHCl vs time (n = 3). Abbreviations: CipHCl, ciprofloxacin HCl; PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
Figure 8
Figure 8
Effect of thickness on the release behavior from medicated electrospun nanofiber mats of PVA:PVAc (50:50) containing 10% w/w CipHCl vs time (n = 3). Abbreviations: CipHCl, ciprofloxacin HCl; PVA, polyvinyl alcohol; PVA/PVAc, polyvinyl acetate.
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