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Comparative Study
. 2011 May 1;5(3):681-6.
doi: 10.1177/193229681100500322.

Reduction of postprandial glycemic excursions in patients with type 1 diabetes: a novel human insulin formulation versus a rapid-acting insulin analog and regular human insulin

Lutz Heinemann  1 , Marcus Hompesch, Frank Flacke, Patrick Simms, Rody Pohl, Kerstin Albus, Andreas Pfützner, Solomon Steiner
Affiliations
Comparative Study

Reduction of postprandial glycemic excursions in patients with type 1 diabetes: a novel human insulin formulation versus a rapid-acting insulin analog and regular human insulin

Lutz Heinemann et al. J Diabetes Sci Technol. .

Abstract

Background: Evaluation of postprandial glycemic excursions in patients with type 1 diabetes with three prandial insulins: VIAject™ (Linjeta™), an ultra-fast insulin (UFI); insulin lispro (LIS); and regular human insulin (RHI).

Methods: After stabilization of preprandial glycemia, 18 patients received a subcutaneous injection with an individualized insulin dose prior to a meal.

Results: Injection of UFI resulted in a more rapid insulin absorption than with either LIS or RHI (time to half-maximal insulin levels: 13.1 ± 5.2 vs 25.4 ± 7.6 and 38.4 ± 19.5 min; p = .001 vs LIS and p < .001 vs RHI, LIS vs. RHI p < .001). Maximal postprandial glycemia was lower with UFI (0-180 min; 157 ± 30 mg/dl; p = .002 vs RHI) and LIS (170 ± 42 mg/dl; p = .668 vs RHI) than after RHI (191 ± 46 mg/dl; RHI vs LIS p = .008). The difference between maximum and minimum glycemia was smaller with UFI (70 ± 17 mg/dl) than with either RHI (91 ± 33 mg/dl; p = .007 vs UFI) or LIS (89 ± 18 mg/dl; p = .011 vs UFI). Also, the area under the blood glucose profile was lower with UFI than with RHI (0-180 min; 21.8 ± 5.8 vs 28.4 ± 7.6 g·min/dl; p < .001).

Conclusions: The rapid absorption of UFI results in a reduction of postprandial glycemic excursions.

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Figures

Figure 1
Figure 1
Mean plasma insulin profiles (A) with baseline correction (mean of the last three samples prior to injection) and mean blood glucose profiles (B) measured by the Biostator, obtained after SC injection of regular human insulin (dashed line), insulin lispro (dotted line), and an ultra-fast insulin (continuous line) in 18 patients with type 1 diabetes.
See this image and copyright information in PMC

References

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