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Review
. 2011 Nov;96(1-4):3-9.
doi: 10.1016/j.prostaglandins.2011.06.004. Epub 2011 Jun 21.

Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function

Louis M Pelus  1 , Jonathan Hoggatt
Affiliations
Review

Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function

Louis M Pelus et al. Prostaglandins Other Lipid Mediat. 2011 Nov.

Abstract

Eicosanoids have been implicated in the physiological regulation of hematopoiesis with pleiotropic effects on hematopoietic stem cells and various classes of lineage restricted progenitor cells. Herein we review the effects of eicosanoids on hematopoiesis, focusing on new findings implicating prostaglandin E(2) in enhancing hematopoietic stem cell engraftment by enhancing stem cell homing, survival and self-renewal. We also describe a role for cannabinoids in hematopoiesis. Lastly, we discuss the yin and yang of various eicosanoids in modulating hematopoietic stem and progenitor cell functions and summarize potential strategies to take advantage of these effects for therapeutic benefit for hematopoietic stem cell transplantation.

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Figures

Figure 1
Figure 1
Blood cell development is a hierarchical process with self-renewal and maturational divisions occurring as a continuum under the direction of single or multiple growth factors. Shown is a simplistic representation incorporating current understandings of the hematopoietic process. Specific progenitor cells include the common lymphoid progenitor (CLP), common myeloid progenitor (CMP), granulocyte-monocyte progenitor (GMP), megakaryocyte-erythrocyte progenitor (MEP), the megakaryocyte (CFU-Meg) and erythroid (BFU-E) progenitors and the common macrophage and dendritic cell progenitor (MDP).
See this image and copyright information in PMC

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