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. 1990 Oct;28(10):2362-4.
doi: 10.1128/jcm.28.10.2362-2364.1990.

Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture

J A Levy  1 , A Landay, E T Lennette
Affiliations

Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture

J A Levy et al. J Clin Microbiol. 1990 Oct.

Abstract

The SF strain of human herpesvirus 6 (HHV-6SF) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.

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