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Review
. 2011 Sep;96(3):546-53.
doi: 10.1016/j.fertnstert.2011.05.094. Epub 2011 Jun 30.

Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active antiretrovirals

Vitaly A Kushnir  1 , William Lewis
Affiliations
Review

Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active antiretrovirals

Vitaly A Kushnir et al. Fertil Steril. 2011 Sep.

Abstract

Objective: To review the effects of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in terms of its associated comorbid conditions and the side effects of antiretroviral treatment on fertility.

Design: PubMed computer search to identify relevant articles.

Setting: Research institution.

Patient(s): None.

Intervention(s): None.

Main outcome measure(s): None.

Result(s): Biological alterations in reproductive physiology may account for subfertility in patients infected with HIV. Psychosocial factors in patients with HIV infection may affect their reproductive desires and outcomes. Antiretroviral medications may have direct toxicity on gametes and embryos. Available evidence indicates that fertility treatments can be a safe option for couples with HIV-discordant infection status, although the potential risk of viral transmission cannot be completely eliminated.

Conclusion(s): Because their potential reproductive desires are increasingly becoming a concern in the health care of young HIV-infected patients, additional data are needed to address the effect of HIV and its treatments on their fertility and reproductive outcomes.

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References

    1. Steinbrook R. The AIDS epidemic in 2004. N Engl J Med. 2004;351:115–117. - PubMed
    1. Zarocostas J. WHO and UN slash their estimates of global HIV prevalence. BMJ. 2007;335:1069. - PMC - PubMed
    1. Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) Science. 1983;220:868–871. - PubMed
    1. Barre-Sinoussi F. HIV as the cause of AIDS. Lancet. 1996;348:31–35. - PubMed
    1. Levy JA, Cheng-Mayer C, Dina D, Luciw PA. AIDS retrovirus (ARV-2) clone replicates in transfected human and animal fibroblasts. Science. 1986;232:998–1001. - PubMed