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. 2011 Aug 1;21(15):4520-3.
doi: 10.1016/j.bmcl.2011.05.117. Epub 2011 Jun 12.

Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells

Seo Young Shin  1 , Min Cheol Shin, Ji-Sun Shin, Kyung-Tae Lee, Yong Sup Lee
Affiliations

Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells

Seo Young Shin et al. Bioorg Med Chem Lett. .

Abstract

Sulfuretin is one of major constituents of Rhus verniciflua that exerts anti-inflammatory activities. Some of aurones were synthesized as sulfuretin derivatives and evaluated for their abilities to inhibit NO and PGE(2) production in LPS-induced RAW 264.7 cells in order to reveal the relationship. Of the aurones synthesized in the present study, 2h and 2i, which possess C-6 hydroxyl group in A-ring and methoxy substituents in B-ring, more potently inhibited NO and PGE(2) production and were less cytotoxic than sulfuretin.

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