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. 2011 Oct 28;309(2):128-36.
doi: 10.1016/j.canlet.2011.05.012. Epub 2011 Jun 24.

Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma

Jian-Rong He  1 , Lu-Ying Tang, Dan-Dan Yu, Feng-Xi Su, Er-Wei Song, Ying Lin, Shen-Ming Wang, Guan-Chao Lai, Wei-Qing Chen, Ze-Fang Ren
Affiliations

Epstein-Barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma

Jian-Rong He et al. Cancer Lett. .

Abstract

We investigated IgA and IgG levels against EBV viral capsid antigen (VCA) and nuclear antigen-1 (EBNA-1) in serum of 223 women with breast cancer (BC) and 309 controls in Guangzhou, China. VCA IgA levels were significantly associated with an elevated risk of BC, with adjusted ORs (95%CIs) of 1.70 (1.05-2.76) (seropositivity) and 2.21 (1.11-4.40) (unit increases in OD value). This association was stronger among young, lean, and HER2+ women. The EBNA-1 IgA levels in OD value, but not seropositivity, were associated with an increased risk of BC among ER+, PR+, and HER2+ patients. None of the IgG variables was related to BC. These results suggest the EBV association with BC in an endemic area of nasopharyngeal carcinoma.

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