Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2011 Nov;39(11):2393-400.
doi: 10.1097/CCM.0b013e318225757f.

Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients

Daryl J Kor  1 , Jason Erlich, Michelle N Gong, Michael Malinchoc, Rickey E Carter, Ognjen Gajic, Daniel S Talmor; U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators
Collaborators, Affiliations
Multicenter Study

Association of prehospitalization aspirin therapy and acute lung injury: results of a multicenter international observational study of at-risk patients

Daryl J Kor et al. Crit Care Med. 2011 Nov.

Abstract

Objective: To evaluate the association between prehospitalization aspirin therapy and incident acute lung injury in a heterogeneous cohort of at-risk medical patients.

Design: This is a secondary analysis of a prospective multicenter international cohort investigation.

Setting: Multicenter observational study including 20 US hospitals and two hospitals in Turkey.

Patients: Consecutive, adult, nonsurgical patients admitted to the hospital with at least one major risk factor for acute lung injury.

Interventions: None.

Measurements and main results: Baseline characteristics and acute lung injury risk factors/modifiers were identified. The presence of aspirin therapy and the propensity to receive this therapy were determined. The primary outcome was acute lung injury during hospitalization. Secondary outcomes included intensive care unit and hospital mortality and intensive care unit and hospital length of stay. Twenty-two hospitals enrolled 3855 at-risk patients over a 6-month period. Nine hundred seventy-six (25.3%) were receiving aspirin at the time of hospitalization. Two hundred forty (6.2%) patients developed acute lung injury. Univariate analysis noted a reduced incidence of acute lung injury in those receiving aspirin therapy (odds ratio [OR], 0.65; 95% confidence interval [CI], 0.46-0.90; p = .010). This association was attenuated in a stratified analysis based on deciles of aspirin propensity scores (Cochran-Mantel-Haenszel pooled OR, 0.70; 95% CI, 0.48-1.03; p = .072).

Conclusions: After adjusting for the propensity to receive aspirin therapy, no statistically significant associations between prehospitalization aspirin therapy and acute lung injury were identified; however, a prospective clinical trial to further evaluate this association appears warranted.

PubMed Disclaimer

Conflict of interest statement

The authors have not disclosed any potential conflicts of interest.

Figures

Figure 1
Figure 1
Study participant flow chart.
See this image and copyright information in PMC

Comment in

References

    1. Jepsen S, Herlevsen P, Knudsen P. Antioxidant treatment with n-acetylcyesteine during adult respiratory distress syndrome: a prospective randomized placebo controlled study. Crit Care Med. 1992;20(7):918–923. - PubMed
    1. Thompson BT. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA. 2000;283(15):1995–2002. - PubMed
    1. Wiedemann HP, Arroliga AC, Komara J, et al. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Critical Care Med. 2002;30(1):1–6. - PubMed
    1. Meade MO, Jacka MJ, Cook DJ, et al. Survey of interventions for the prevention and treatment of acute respiratory distress syndrome. Critical Care Med. 2004;32(4):946–954. - PubMed
    1. Zeiher BG, Artigas A, Vincent J-L, et al. Neutrophil elastase inhibition in acute lung injury: Results of the STRIVE study. Critical Care Med. 2004;32(8):1695–1702. - PubMed

Publication types

MeSH terms