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Comparative Study
. 2011 Jul 3;43(8):792-6.
doi: 10.1038/ng.875.

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

Zhibin Hu  1 , Chen Wu, Yongyong Shi, Huan Guo, Xueying Zhao, Zhihua Yin, Lei Yang, Juncheng Dai, Lingmin Hu, Wen Tan, Zhiqiang Li, Qifei Deng, Jiucun Wang, Wei Wu, Guangfu Jin, Yue Jiang, Dianke Yu, Guoquan Zhou, Hongyan Chen, Peng Guan, Yijiang Chen, Yongqian Shu, Lin Xu, Xiangyang Liu, Li Liu, Ping Xu, Baohui Han, Chunxue Bai, Yuxia Zhao, Haibo Zhang, Ying Yan, Hongxia Ma, Jiaping Chen, Mingjie Chu, Feng Lu, Zhengdong Zhang, Feng Chen, Xinru Wang, Li Jin, Jiachun Lu, Baosen Zhou, Daru Lu, Tangchun Wu, Dongxin Lin, Hongbing Shen
Affiliations
Comparative Study

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

Zhibin Hu et al. Nat Genet. .

Abstract

Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a genome-wide association scan in 5,408 subjects (2,331 individuals with lung cancer (cases) and 3,077 controls) followed by a two-stage validation among 12,722 subjects (6,313 cases and 6,409 controls). The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively). Two of these loci (13q12.12 and 22q12.2) were newly identified in the Chinese population. These results suggest that genetic variants in 3q28, 5p15.33, 13q12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese.

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