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. 1990;19(3-4):203-16.

Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques

C C Tsai  1 , K E Follis, K Snyder, S Windsor, M E Thouless, L Kuller, W R Morton
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  • PMID: 2172540

Maternal transmission of type D simian retrovirus (SRV-2) in pigtailed macaques

C C Tsai et al. J Med Primatol. 1990.

Abstract

Pregnant macaques were used as a natural model for maternal-infant transmission of SRV-2 retrovirus. Fifty-one pregnant females were placed into one of four virus/antibody groups. Nonviremic mothers produced 100% virus-negative offspring at birth. In contrast, viremic mothers produced offspring which were 17% virus-negative and 83% virus-positive at birth. SRV-2 infection occurred principally in utero by the transplacental route. Infants born to viremic mothers exhibited low birth weight, prematurity, high perinatal death, and increased incidence of SAIDS.

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