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Review
. 2011:111:63-9.
doi: 10.1007/978-3-7091-0693-8_11.

Intracranial hemorrhage: mechanisms of secondary brain injury

Josephine Lok  1 , Wendy Leung, Sarah Murphy, William Butler, Natan Noviski, Eng H Lo
Affiliations
Review

Intracranial hemorrhage: mechanisms of secondary brain injury

Josephine Lok et al. Acta Neurochir Suppl. 2011.

Abstract

ICH is a disease with high rates of mortality and morbidity, with a substantial public health impact. Spontaneous ICH (sICH) has been extensively studied, and a large body of data has been accumulated on its pathophysiology. However, the literature on traumatic ICH (tICH) is limited, and further investigations of this important topic are needed. This review will highlight some of the cellular pathways in ICH with an emphasis on the mechanisms of secondary injury due to heme toxicity and to events in the coagulation process that are common to both sICH and tICH.

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Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest.

Figures

Figure 1
Figure 1
Representative pathways of secondary brain injury after ICH.
See this image and copyright information in PMC

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